Article
Multiple polymorphisms within the PLCE1 are associated with esophageal cancer via promoting the gene expression in a Chinese Kazakh population.
Gene - 10 Nov 2013
Cui Xiao-Bin, Chen Yun-Zhao, Pang Xue-Lian, Liu Wei, Hu Jian-Ming, Li Shu-Gang, Yang Lan, Zhang Wen-Jie, Liu Chun-Xia, Cao Yu-Wen, Jiang Jin-Fang, Gu Wen-Yi, Pang James, Yang Lei, Yuan Xiang-Lin, Yu Shi-Ying, Li Feng
Abstract excerpt
Although recent genome-wide association studies of esophageal squamous cell carcinoma (ESCC) identified a susceptibility locus in phospholipase C epsilon 1 (PLCE1) in Chinese Han populations, few studies further confirmed these findings in pure Kazakh population in which there are higher incidence and mortality of ESCC. Here, we investigated the potential associations between 19 SNPs of PLCE1 and susceptibility...
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