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Article

Is diclofenac a valuable CYP2C9 probe in humans?

European journal of clinical pharmacology - 1 Jan 2000

Morin S, Loriot M A, Poirier J M, Tenneze L, Beaune P H, Funck-Brentano C, Jaillon P, Becquemont L

Abstract excerpt

INTRODUCTION: Besides the low therapeutic index drug tolbutamide, there is no validated in vivo probe to assess the genetically determined CYP2C9 activity in humans. The in vitro CYP2C9-specific substrate diclofenac might be a valuable, well-tolerated probe candidate. In order to validate diclofe...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11294368
DOI: 10.1007/s002280000240

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11294368-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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