Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

KIAA1199 deficiency enhances skeletal stem cell differentiation to osteoblasts and promotes bone regeneration

10 Apr 2023

Abstract excerpt

Upon transplantation, skeletal stem cells (also known as bone marrow stromal or mesenchymal stem cells) can regulate bone regeneration by producing secreted factors. Here, we identify KIAA1199 as a bone marrow stromal cell-secreted factor in vitro and in vivo. KIAA1199 plasma levels of patients positively correlate with osteoporotic fracture risk and expression levels of KIAA1199 in patient bone marrow stromal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Dental Protein Studies
Share to Bone Metabolism and Diseases
Share to S100 Proteins and Annexins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37037828
DOI: 10.1038/s41467-023-37651-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KIAA1199 deficiency enhances skeletal stem cell differentiation to osteoblasts and promotes bone regenerationPMID 37037828Read ↗

Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disordersSemantic proximity Read ↗

AD-HIES Fracture Healing Impaired by STAT3 Dysfunction Affecting Stem Cell MobilizationSemantic proximity Read ↗

TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization.Semantic proximity Read ↗

STAT3 is critical for skeletal development and bone homeostasis by regulating osteogenesisSemantic proximity Read ↗

Genomic variants within chromosome 14q32.32 regulate bone mass through MARK3 signaling in osteoblasts.Semantic proximity Read ↗

Osteoclast-independent osteocyte dendrite defects in mice bearing the osteogenesis imperfecta-causing Sp7 R342C mutation.Semantic proximity Read ↗

Stat3 loss in mesenchymal progenitors causes Job syndrome-like skeletal defects by reducing Wnt/β-catenin signaling.Semantic proximity Read ↗

Loss of Signal Transducer and Activator of Transcription 3 Impaired the Osteogenesis of Mesenchymal Progenitor Cells in Vivo and in VitroSemantic proximity Read ↗

JAK-STAT and bone metabolismSemantic proximity Read ↗

Loss of signal transducer and activator of transcription 3 impaired the osteogenesis of mesenchymal progenitor cells in vivo and in vitroSemantic proximity Read ↗

Knockdown of SERPINB2 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the Wnt/β-catenin signalling pathwaySemantic proximity Read ↗

Knockdown of SERPINB2 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the Wnt/β-catenin signalling pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.