Enrichment of PI3K-AKT-mTOR Pathway Activation in Hepatic Metastases from Breast Cancer.

doi:10.1158/1078-0432.CCR-16-2656

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Enrichment of PI3K-AKT-mTOR Pathway Activation in Hepatic Metastases from Breast Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2017

Pierobon Mariaelena, Ramos Corinne, Wong Shukmei, Hodge K Alex, Aldrich Jessica, Byron Sara, Anthony Stephen P, Robert Nicholas J, Northfelt Donald W, Jahanzeb Mohammad, Vocila Linda, Wulfkuhle Julia, Gambara Guido, Gallagher Rosa I, Dunetz Bryant, Hoke Nicholas, Dong Ting, Craig David W, Cristofanilli Massimo, Leyland-Jones Brian, Liotta Lance A, O'Shaughnessy Joyce A, Carpten John D, Petricoin Emanuel F

Abstract excerpt

Purpose: Little is known about the molecular signatures associated with specific metastatic sites in breast cancer. Using comprehensive multi-omic molecular profiling, we assessed whether alterations or activation of the PI3K-AKT-mTOR pathway is associated with specific sites of breast cancer metastasis.Experimental Design: Next-generation sequencing-based whole-exome sequencing was coupled with reverse-phase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liver Neoplasms

Share to Phosphatidylinositol 3-Kinases

Share to Protein Kinases

Share to Proto-Oncogene Proteins c-akt

Share to Ribosomal Protein S6 Kinases, 70-kDa

Share to Signal Transduction

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 28446508
DOI: 10.1158/1078-0432.CCR-16-2656
PMCID: PMC5564311

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enrichment of PI3K-AKT-mTOR Pathway Activation in Hepatic Metastases from Breast Cancer.PMID 28446508Read ↗

Mutational Landscape of PI3K-AKT-mTOR Pathway in Breast Cancer: Implications for Targeted TherapeuticsSemantic proximity Read ↗

Identification of single nucleotide polymorphisms of the PI3K-AKT-mTOR pathway as a risk factor of central nervous system metastasis in metastatic breast cancer.Semantic proximity Read ↗

Functional activation of the AKT-mTOR signalling axis in a real-world metastatic breast cancer cohort.Semantic proximity Read ↗

Frequency of genetic alterations differs in advanced breast cancer between metastatic sites.Semantic proximity Read ↗

Targeting PI3K/AKT/mTOR Pathway in Breast Cancer: From Biology to Clinical ChallengesSemantic proximity Read ↗

Association of PI3K Pathway Mutations with Early Positron-Emission Tomography/CT Imaging Response after Radioembolization for Breast Cancer Liver Metastases: Results of a Single-Center Retrospective Pilot Study.Semantic proximity Read ↗

Patient-derived xenografts of triple-negative breast cancer reproduce molecular features of patient tumors and respond to mTOR inhibition.Semantic proximity Read ↗

PI3K: A master regulator of brain metastasis‐promoting macrophages/microgliaSemantic proximity Read ↗

Integrated genomic and transcriptomic analysis reveals unique characteristics of hepatic metastases and pro-metastatic role of complement C1q in pancreatic ductal adenocarcinomaSemantic proximity Read ↗

Clinicopathogenomic analysis of AKT1-PIK3CA-PTEN-altered luminal metastatic breast cancer in JapanSemantic proximity Read ↗

PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer.Semantic proximity Read ↗

A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.