Article
Mutations targeting the coagulation pathway are enriched in brain metastases.
Scientific reports - 26 Jul 2017
Richichi Cristina, Fornasari Lorenzo, Melloni Giorgio E M, Brescia Paola, Patanè Monica, Del Bene Massimiliano, Mustafa Dana A M, Kros Johan M, Pollo Bianca, Pruneri Giancarlo, Sciandivasci Angela, Munzone Elisabetta, DiMeco Francesco, Pelicci Pier Giuseppe, Riva Laura, Pelicci Giuliana
Abstract excerpt
Brain metastases (BMs) are the most common malignancy of the central nervous system. Recently it has been demonstrated that plasminogen activator inhibitor serpins promote brain metastatic colonization, suggesting that mutations in serpins or other members of the coagulation cascade can provide critical advantages during BM formation. We performed whole-exome sequencing on matched samples of breast cancer and BMs...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.