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Divergence of DNA tumor mutations in cerebrospinal fluid in metastatic breast cancer patients with leptomeningeal metastases.

Breast (Edinburgh, Scotland) - 1 Feb 2026

Wessels Peter H, Cornelissen Sten, Monkhorst Kim, Sonke Gabe S, Broeks Annegien, Linders Dorothe, van den Broek Daan, Boelens Mirjam C, Brandsma Dieta

Abstract excerpt

PURPOSE: To study differences in genetic alterations between primary breast cancer, systemic metastases, and cerebrospinal fluid (CSF) in patients with leptomeningeal metastases (LM). MATERIAL AND METHODS: Breast cancer patients with confirmed or probable LM and available primary tumor tissue were selected from a CSF-biobank study of the Netherlands Cancer Institute. Genetic analysis of cell-free DNA (cfDNA) in...

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Identifiers

PMID: 41496422
DOI: 10.1016/j.breast.2025.104674
PMCID: PMC12813069

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ESR1
PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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