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Article

Nitration-mediated deficiency of cystathionine β-synthase activity accelerates the progression of hyperhomocysteinemia.

Free radical biology & medicine - 1 Dec 2017

Wang Huanyuan, Sun Qi, Zhou Yi, Zhang Hui, Luo Chenghua, Xu Jiahui, Dong Yu, Wu Ye, Liu Huirong, Wang Wen

Abstract excerpt

Deficiency of cystathionine β-synthase (CBS) activity is the most common cause of increased homocysteine (Hcy). However, until now the underlying mechanisms why CBS activity decreased still remain unresolved. The goal of this study was to explore the contribution of nitrative stress to deficiency of CBS activity, and further identify the possible nitration sites of CBS protein. Results showed that in elderly...

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PMID: 29102635
DOI: 10.1016/j.freeradbiomed.2017.10.389

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CBS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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