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Article

Natural Selection on Genes Related to Cardiovascular Health in High-Altitude Adapted Andeans.

American journal of human genetics - 2 Nov 2017

Crawford Jacob E, Amaru Ricardo, Song Jihyun, Julian Colleen G, Racimo Fernando, Cheng Jade Yu, Guo Xiuqing, Yao Jie, Ambale-Venkatesh Bharath, Lima João A, Rotter Jerome I, Stehlik Josef, Moore Lorna G, Prchal Josef T, Nielsen Rasmus

Abstract excerpt

The increase in red blood cell mass (polycythemia) due to the reduced oxygen availability (hypoxia) of residence at high altitude or other conditions is generally thought to be beneficial in terms of increasing tissue oxygen supply. However, the extreme polycythemia and accompanying increased mortality due to heart failure in chronic mountain sickness most likely reduces fitness. Tibetan highlanders have adapted...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29100088
DOI: 10.1016/j.ajhg.2017.09.023
PMCID: PMC5673686

Genes

BRINP3
NOS2
TBX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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