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Article

Essential structural elements in tRNA(Pro) for EF-P-mediated alleviation of translation stalling.

Nature communications - 24 May 2016

Katoh Takayuki, Wohlgemuth Ingo, Nagano Masanobu, Rodnina Marina V, Suga Hiroaki

Abstract excerpt

The ribosome stalls on translation of polyproline sequences due to inefficient peptide bond formation between consecutive prolines. The translation factor EF-P is able to alleviate this stalling by accelerating Pro-Pro formation. However, the mechanism by which EF-P recognizes the stalled complexes and accelerates peptide bond formation is not known. Here, we use genetic code reprogramming through a flexible...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27216360
DOI: 10.1038/ncomms11657
PMCID: PMC4890201

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