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Article

Defects in recombination activity caused by somatic and germline mutations in the multimerization/BRCA2 binding region of human RAD51 protein.

DNA repair - 1 Dec 2017

Silva Michelle C, Bryan Katie E, Morrical Milagros D, Averill April M, Dragon Julie, Wiegmans Adrian P, Morrical Scott W

Abstract excerpt

The human RAD51 recombinase possesses DNA pairing and strand exchange activities that are essential for the error-free, homology-directed repair of DNA double-strand breaks. The recombination activities of RAD51 are activated upon its assembly into presynaptic filaments on single-stranded DNA at resected DSB ends. Defects in filament assembly caused by mutations in RAD51 or its regulators such as BRCA2 are...

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Share to BRCA2 Protein
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mutation, Missense

Share to Protein Interaction Domains and Motifs

Share to Protein Multimerization

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Source

Open in PubMed Open full text

Identifiers

PMID: 29100040
DOI: 10.1016/j.dnarep.2017.10.008
PMCID: PMC5699509

Genes

RAD51
BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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