Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenome-wide association studies identify DNA methylation associated with kidney function.

Nature communications - 3 Nov 2017

Chu Audrey Y, Tin Adrienne, Schlosser Pascal, Ko Yi-An, Qiu Chengxiang, Yao Chen, Joehanes Roby, Grams Morgan E, Liang Liming, Gluck Caroline A, Liu Chunyu, Coresh Josef, Hwang Shih-Jen, Levy Daniel, Boerwinkle Eric, Pankow James S, Yang Qiong, Fornage Myriam, Fox Caroline S, Susztak Katalin, Köttgen Anna

Abstract excerpt

Chronic kidney disease (CKD) is defined by reduced estimated glomerular filtration rate (eGFR). Previous genetic studies have implicated regulatory mechanisms contributing to CKD. Here we present epigenome-wide association studies of eGFR and CKD using whole-blood DNA methylation of 2264 ARIC Study and 2595 Framingham Heart Study participants to identify epigenetic signatures of kidney function. Of 19 CpG sites...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CCAAT-Enhancer-Binding Protein-beta
Share to CpG Islands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to E1A-Associated p300 Protein

Share to Glomerular Filtration Rate

Share to Kidney

Share to Prohibitins

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 6

Share to Renal Insufficiency, Chronic

Source

Open in PubMed Open full text

Identifiers

PMID: 29097680
DOI: 10.1038/s41467-017-01297-7
PMCID: PMC5668367

Genes

PTPN6
PHB2
EBF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenome-wide association studies identify DNA methylation associated with kidney function.PMID 29097680Read ↗

Meta-analyses identify DNA methylation associated with kidney function and damageSemantic proximity Read ↗

DNA hypermethylation and DNA hypomethylation is present at different loci in chronic kidney diseaseSemantic proximity Read ↗

Cytosine methylation changes in enhancer regions of core pro-fibrotic genes characterize kidney fibrosis developmentSemantic proximity Read ↗

Genome-wide DNA methylation analysis revealed epigenetic mechanism underlying end stage renal diseaseSemantic proximity Read ↗

Genome-wide DNA methylation analysis revealed epigenetic mechanism underlying end-stage renal diseaseSemantic proximity Read ↗

Genome-wide DNA methylation analysis revealed epigenetic mechanism underlying end stage renal diseaseSemantic proximity Read ↗

Trans-ethnic genome-wide association study of kidney function provides novel insight into effector genes and causal effects on kidney-specific disease aetiologiesSemantic proximity Read ↗

A methylation risk score for chronic kidney disease: a HyperGEN study.Semantic proximity Read ↗

Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci.Semantic proximity Read ↗

Genetic and epigenetic factors influencing chronic kidney diseaseSemantic proximity Read ↗

Unraveling the epigenetic code: human kidney DNA methylation and chromatin dynamics in renal disease developmentSemantic proximity Read ↗

Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.