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Article

Promises and pitfalls of immune-based strategies for Huntington's disease

1 Jan 2017

Abstract excerpt

Huntington's disease (HD) is an autosomal-dominant neurodegenerative disease characterized by the selective loss of neurons in the striatum and cortex, leading to progressive motor dysfunction, cognitive decline and behavioral symptoms. HD is caused by a trinucleotide (CAG) repeat expansion in the gene encoding for huntingtin. Several studies have suggested that inflammation is an important feature of HD and it...

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PMID: 29089980
DOI: 10.4103/1673-5374.215245

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