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Article

Transcriptional dysregulation of inflammatory/immune pathways after active vaccination against Huntington′s disease

24 Aug 2015

Abstract excerpt

Immunotherapy, both active and passive, is increasingly recognized as a powerful approach to a wide range of diseases, including Alzheimer's and Parkinson's. Huntington's disease (HD), an autosomal dominant disorder triggered by misfolding of huntingtin (HTT) protein with an expanded polyglutamine tract, could also benefit from this approach. Individuals can be identified genetically at the earliest stages of...

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PMID: 26307082
DOI: 10.1093/hmg/ddv335

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