Article
Characterization of embB mutations involved in ethambutol resistance in multi-drug resistant Mycobacterium tuberculosis isolates in Zambia.
Tuberculosis (Edinburgh, Scotland) - 1 Mar 2022
Bwalya Precious, Solo Eddie S, Chizimu Joseph Y, Shrestha Dipti, Mbulo Grace, Thapa Jeewan, Nakajima Chie, Suzuki Yasuhiko
Abstract excerpt
BACKGROUND: Ethambutol (EMB) is an important anti-tuberculosis drug used in the management of multi-drug resistant tuberculosis (MDR-TB). Mutations in embB are the major mechanism of resistance. This study investigated embB mutations among MDR-TB isolates and analyzed their correlations with phenotypic drug susceptibility testing (DST) in Zambia. METHOD: A total of 132 MDR-TB isolates were collected from January...
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