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Article

Bioluminescence imaging of G protein-coupled receptor activation in living mice.

Nature communications - 27 Oct 2017

Kono Mari, Conlon Elizabeth G, Lux Samantha Y, Yanagida Keisuke, Hla Timothy, Proia Richard L

Abstract excerpt

G protein-coupled receptors (GPCRs), a superfamily of cell-surface receptors involved in virtually all physiological processes, are the major target class for approved drugs. Imaging GPCR activation in real time in living animals would provide a powerful way to study their role in biology and disease. Here, we describe a mouse model that enables the bioluminescent detection of GPCR activation in real time by...

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Identifiers

PMID: 29079828
DOI: 10.1038/s41467-017-01340-7
PMCID: PMC5660082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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