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Article

Nox4 NADPH oxidase contributes to smooth muscle cell phenotypes associated with unstable atherosclerotic plaques.

Redox biology - 1 Jan 2014

Xu Shaoping, Chamseddine Ali H, Carrell Samuel, Miller Francis J

Abstract excerpt

Plaque instability associated with acute coronary syndromes results in part from apoptosis and senescence of cells within the atherosclerotic (AS) lesion. Increased cellular oxidative stress has been proposed to contribute to plaque progression and changes in composition, leading to plaque instability. Our objective was to examine the role of NADPH oxidase in smooth muscle cell (SMC) phenotypes associated with an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myocytes, Smooth Muscle

Share to NADH, NADPH Oxidoreductases

Share to NADPH Oxidases

Share to Plaque, Atherosclerotic

Share to Receptors, LDL

Source

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Identifiers

PMID: 24936437
DOI: 10.1016/j.redox.2014.04.004
PMCID: PMC4052526

Genes

LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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