Article
Mitochondrial integrity and function in atherogenesis.
Circulation - 30 Jul 2002
Ballinger Scott W, Patterson Cam, Knight-Lozano Cynthia A, Burow David L, Conklin Caryl A, Hu Zhaoyong, Reuf Johannes, Horaist Chris, Lebovitz Russell, Hunter Glenn C, McIntyre Ken, Runge Marschall S
Abstract excerpt
BACKGROUND: Coronary atherosclerotic disease remains the leading cause of death in the Western world. Although the exact sequence of events in this process is controversial, reactive oxygen and nitrogen species (RS) likely play an important role in vascular cell dysfunction and atherogenesis. Oxidative damage to the mitochondrial genome with resultant mitochondrial dysfunction is an important consequence of...
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