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Article

Proteasomal processing of the viral replicase ORF1 facilitates HEV-induced liver fibrosis

12 Mar 2025

Abstract excerpt

Chronic infections with hepatitis E virus (HEV), especially those of genotype 3 (G3), frequently lead to liver fibrosis and cirrhosis in patients. However, the causation and mechanism of liver fibrosis triggered by chronic HEV infection remain poorly understood. Here, we found that the viral multiple-domain replicase (ORF1) undergoes unique ubiquitin–proteasomal processing leading to formation of the H EV- D...

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PMID: 40073055
DOI: 10.1073/pnas.2419946122

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