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Article

The natural product mensacarcin induces mitochondrial toxicity and apoptosis in melanoma cells.

The Journal of biological chemistry - 22 Dec 2017

Plitzko Birte, Kaweesa Elizabeth N, Loesgen Sandra

Abstract excerpt

Mensacarcin is a highly oxygenated polyketide that was first isolated from soil-dwelling Streptomyces bacteria. It exhibits potent cytostatic properties (mean of 50% growth inhibition = 0.2 μm) in almost all cell lines of the National Cancer Institute (NCI)-60 cell line screen and relatively selective cytotoxicity against melanoma cells. Moreover, its low COMPARE correlations with known standard antitumor agents...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29074620
DOI: 10.1074/jbc.M116.774836
PMCID: PMC5743083

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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