Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis.

doi:10.1186/s40478-019-0712-8

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Article

Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis.

Acta neuropathologica communications - 10 Apr 2019

Sundstrøm Terje, Prestegarden Lars, Azuaje Francisco, Aasen Synnøve Nymark, Røsland Gro Vatne, Varughese Jobin K, Bahador Marzieh, Bernatz Simon, Braun Yannick, Harter Patrick N, Skaftnesmo Kai Ove, Ingham Elizabeth S, Mahakian Lisa M, Tam Sarah, Tepper Clifford G, Petersen Kjell, Ferrara Katherine W, Tronstad Karl Johan, Lund-Johansen Morten, Beschorner Rudi, Bjerkvig Rolf, Thorsen Frits

Abstract excerpt

Melanoma patients carry a high risk of developing brain metastases, and improvements in survival are still measured in weeks or months. Durable disease control within the brain is impeded by poor drug penetration across the blood-brain barrier, as well as intrinsic and acquired drug resistance. Augmented mitochondrial respiration is a key resistance mechanism in BRAF-mutant melanomas but, as we show in this...

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Identifiers

PMID: 30971321
DOI: 10.1186/s40478-019-0712-8
PMCID: PMC6456988

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BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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