Article

Discovery of A Chimeric Polyketide Family as Cancer Immunogenic Chemotherapeutic Leads

2024-11-06

Abstract excerpt

Discovery of cancer immunogenic chemotherapeutics represents an emerging, highly promising direction for cancer treatment that uses a chemical drug to achieve the efficacy of both chemotherapy and immunotherapy. Herein we report a high-throughput screening platform and the subsequent discovery of a new class of cancer immunogenic chemotherapeutic leads. Our platform integrates informatics-based activity metabolomi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 83ab52e6-604d-5e26-9094-4fbcc8259bae
DOI: 10.1101/2024.11.05.622009

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Discovery of A Chimeric Polyketide Family as Cancer Immunogenic Chemotherapeutic LeadsDOI 10.1101/2024.11.05.622009Read

Discovery of a Chimeric Polyketide Family as Cancer Immunogenic Chemotherapeutic LeadsSemantic proximity Read

Microbial natural products: molecular blueprints for antitumor drugsSemantic proximity Read

Bioinformatics-based stereochemical elucidation of MM 46115: an unusual antiviral spirotetronate that inhibits clathrin-mediated endocytosisSemantic proximity Read

Natural Product Drug Discovery in the Next MillenniumSemantic proximity Read

Pattern-Based Genome Mining Guides Discovery of the Antibiotic Indanopyrrole A from a Marine StreptomyceteSemantic proximity Read

Genome mining reveals uncommon alkylpyrones as type III PKS products from myxobacteriaSemantic proximity Read

Discovery of unusual dimeric piperazyl cyclopeptides encoded by a Lentzea flaviverrucosa DSM 44664 biosynthetic superclusterSemantic proximity Read

Manumycin Polyketides Act as Molecular Glues Between UBR7 and P53 to Impair Breast Cancer PathogenicitySemantic proximity Read

A multiproducer microbiome generates chemical diversity in the marine sponge Mycale hentscheliSemantic proximity Read

Structure Determination and Interception of Biosynthetic Intermediates for the Plantazolicin Class of Highly Discriminating AntibioticsSemantic proximity Read

Bacterial Biosynthetic Gene Clusters Encoding the Anti-cancer Haterumalide Class of MoleculesSemantic proximity Read

Bioinformatic and mechanistic analysis of the palmerolide PKS-NRPS biosynthetic pathway from the microbiome of an Antarctic ascidianSemantic proximity Read