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Article

Interactions of the natural product kendomycin and the 20S proteasome.

Journal of molecular biology - 9 Sept 2014

Beck Philipp, Heinemeyer Wolfgang, Späth Anna-Lena, Elnakady Yasser, Müller Rolf, Groll Michael

Abstract excerpt

Natural products are a valuable source for novel lead structures in drug discovery, but for the majority of isolated bioactive compounds, the cellular targets are unknown. The structurally unique ansa-polyketide kendomycin (KM) was reported to exert its potent cytotoxic effects via impairment of the ubiquitin proteasome system, but the exact mode of action remained unclear. Here, we present a systematic...

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Identifiers

PMID: 25038530
DOI: 10.1016/j.jmb.2014.06.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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