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Discovery of a Chimeric Polyketide Family as Cancer Immunogenic Chemotherapeutic Leads

28 Dec 2024

Abstract excerpt

Discovery of cancer immunogenic chemotherapeutics represents an emerging, highly promising direction for cancer treatment that uses a chemical drug to achieve the efficacy of both chemotherapy and immunotherapy. Herein, we report a high-throughput screening platform and the subsequent discovery of a new class of cancer immunogenic chemotherapeutic leads. Our platform integrates informatics-based activity...

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PMID: 39731542
DOI: 10.1021/jacs.4c09582

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