Article
Polymethoxyflavones from Gardenia oudiepe (Rubiaceae) induce cytoskeleton disruption-mediated apoptosis and sensitize BRAF-mutated melanoma cells to chemotherapy.
Chemico-biological interactions - 1 Jul 2020
Gonçalves de Oliveira-Júnior Raimundo, Marcoult-Fréville Nolwenn, Prunier Grégoire, Beaugeard Laureen, Beserra de Alencar Filho Edilson, Simões Mourão Eduard David, Michel Sylvie, Quintans-Júnior Lucindo José, Guedes da Silva Almeida Jackson Roberto, Grougnet Raphaël, Picot Laurent
Abstract excerpt
A series of 10 natural and semisynthetic flavonoids (1 to 10) were obtained from Gardenia oudiepe (Rubiaceae), an endemic plant from New Caledonia. Most of them were polymethoxylated flavones (PMFs) of rare occurrence. After a cell viability screening test, PMFs 2 and 3 showed significant cytotoxic activity against A2058 human melanoma cells (IC50 = 3.92 and 8.18 μM, respectively) and were selected for in-depth...
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