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Article

Colletofragarone A2 and Colletoins A-C from a Fungus Colletotrichum sp. Decrease Mutant p53 Levels in Cells.

Journal of natural products - 24 Dec 2021

Sadahiro Yusaku, Hitora Yuki, Tsukamoto Sachiko

Abstract excerpt

p53 is frequently mutated in tumor cells. Mutant p53 (mut p53) accumulates in cells to promote cancer progression, invasion, and metastasis, and it is attracting attention as a target for cancer therapies. In this study, we used immunofluorescence staining of Saos-2 cells harboring doxycycline-inducible p53R175H [Saos-2 (p53R175H) cells] to search for compounds from natural sources that can target mut p53 and...

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PMID: 34854682
DOI: 10.1021/acs.jnatprod.1c00913

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