Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer.

doi:10.1002/mc.22748

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Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer.

Molecular carcinogenesis - 1 Feb 2018

Feng Yun, Wang Yanru, Liu Hongliang, Liu Zhensheng, Mills Coleman, Owzar Kouros, Xie Jichun, Han Younghun, Qian David C, Hung Rj Rayjean J, Brhane Yonathan, McLaughlin John, Brennan Paul, Bickeböller Heike, Rosenberger Albert, Houlston Richard S, Caporaso Neil, Landi Maria Teresa, Brüske Irene, Risch Angela, Ye Yuanqing, Wu Xifeng, Christiani David C, Amos Christopher I, Wei Qingyi

Abstract excerpt

The P38MAPK pathway participates in regulating cell cycle, inflammation, development, cell death, cell differentiation, and tumorigenesis. Genetic variants of some genes in the P38MAPK pathway are reportedly associated with lung cancer risk. To substantiate this finding, we used six genome-wide association studies (GWASs) to comprehensively investigate the associations of 14 904 single nucleotide polymorphisms...

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PMID: 29071797
DOI: 10.1002/mc.22748
PMCID: PMC6128286

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