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Article

Comprehensive functional interrogation of susceptibility loci in GWASs identified KIAA0391 as a novel oncogenic driver via regulating pyroptosis in NSCLC.

Cancer letters - 31 Mar 2024

Zhang Erbao, Sun Qi, Zhang Chang, Ma Huimin, Zhang Jing, Ding Yue, Wang Guoqing, Jin Chen, Jin Chenying, Fu Yating, Yan Caiwang, Zhu Meng, Wang Cheng, Dai Juncheng, Jin Guangfu, Hu Zhibin, Shen Hongbing, Ma Hongxia

Abstract excerpt

Approximately 51 non-small-cell lung cancer (NSCLC) risk loci have been identified by genome-wide association studies (GWASs). We conducted a high throughput RNA-interference (RNAi) screening to identify the candidate causal genes in NSCLC risk loci. KIAA0391 at 14q13.1 had the highest score and could promote proliferation and metastasis of NSCLC in vitro and in vivo. We next prioritized rs3783313 as a causal...

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PMID: 38262497
DOI: 10.1016/j.canlet.2024.216646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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