Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RAG2’s Acidic Hinge Restricts Repair-Pathway Choice and Promotes Genomic Stability

29 Aug 2013

Abstract excerpt

V(D)J recombination-associated DNA double-strand breaks (DSBs) are normally repaired by the high-fidelity classical nonhomologous end-joining (cNHEJ) machinery. Previous studies implicated the recombination-activating gene (RAG)/DNA postcleavage complex (PCC) in regulating pathway choice by preventing access to inappropriate repair mechanisms such as homologous recombination (HR) and alternative NHEJ (aNHEJ)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23994475
DOI: 10.1016/j.celrep.2013.07.041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RAG2’s Acidic Hinge Restricts Repair-Pathway Choice and Promotes Genomic StabilityPMID 23994475Read ↗

RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination.Semantic proximity Read ↗

ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells.Semantic proximity Read ↗

Role of recombination activating genes in the generation of antigen receptor diversity and beyond.Semantic proximity Read ↗

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining PathwaySemantic proximity Read ↗

Crystal structure of the V(D)J recombinase RAG1-RAG2.Semantic proximity Read ↗

Rag mutations reveal robust alternative end joining.Semantic proximity Read ↗

The toposiomerase IIIalpha-RMI1-RMI2 complex orients human Bloom’s syndrome helicase for efficient disruption of D-loopsSemantic proximity Read ↗

The ERCC6L2-MRI-KU complex coordinates NHEJ at staggered DNA double-strand breaksSemantic proximity Read ↗

Human RAG mutations: biochemistry and clinical implications.Semantic proximity Read ↗

Full-length RAG1 promotes contact with coding and intersignal sequences in RAG protein complexes bound to recombination signals paired in cis.Semantic proximity Read ↗

The pendulum of the Ku-Ku clockSemantic proximity Read ↗

Repair of double-strand breaks by end joining.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.