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Article

It takes two: communication between homologous alleles preserves genomic stability during V(D)J recombination.

Nucleus (Austin, Tex.) - 1 Jan 2000

Brandt Vicky L, Hewitt Susannah L, Skok Jane A

Abstract excerpt

Chromosome pairing is involved in X chromosome inactivation, a classic instance of monoallelic gene expression. Antigen receptor genes are also monoallelically expressed ("allelically excluded") by B and T lymphocytes, and we asked whether pairing contributed to the regulation of V(D)J recombination at these loci. We found that homologous immunoglobulin (Ig) alleles pair up during recombination. Homologous Ig...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21327101
DOI: 10.4161/nucl.1.1.10595
PMCID: PMC3035125

Genes

ATM
RAG1
RAG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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