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Article

LOX-1 mediated phenotypic switching of pulmonary arterial smooth muscle cells contributes to hypoxic pulmonary hypertension.

European journal of pharmacology - 5 Jan 2018

Zhang Weifang, Zhu Tiantian, Wu Weihua, Ge Xiaoyue, Xiong Xiaoming, Zhang Zheng, Hu Changping

Abstract excerpt

In pulmonary hypertension (PH), pulmonary arterial smooth muscle cells (PASMCs) are dedifferentiated, undergoing a contractile-to-synthetic phenotypic switching. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) plays diverse roles in the cardiovascular system, but its contribution to PH remains to be fully defined. The present study was undertaken to explore the role of LOX-1 in PASMCs...

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Share to Cell Dedifferentiation
Share to Cell Hypoxia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ether-A-Go-Go Potassium Channels

Share to Hypertension, Pulmonary

Share to Mitogen-Activated Protein Kinase 1

Share to Mitogen-Activated Protein Kinase 3

Share to Pulmonary Artery

Share to Scavenger Receptors, Class E

Source

Identifiers

PMID: 29069578
DOI: 10.1016/j.ejphar.2017.10.037

Genes

LOX
SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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