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Article

Plasma exosomes confer hypoxic pulmonary hypertension by transferring LOX-1 cargo to trigger phenotypic switching of pulmonary artery smooth muscle cells.

Biochemical pharmacology - 1 Jan 2023

Huang Ning, Wang Di, Zhu Tian-Tian, Ge Xiao-Yue, Liu Hong, Yao Mao-Zhong, Guo Yan-Zi, Peng Jun, Wang Qing, Zhang Zheng, Hu Chang-Ping

Abstract excerpt

The pulmonary vascular remodeling (PVR), the pathological basis of pulmonary hypertension (PH), entails pulmonary artery smooth muscle cells (PASMCs) phenotypic switching, but appreciation of the underlying mechanisms is incomplete. Exosomes, a novel transfer machinery enabling delivery of its cargos to recipient cells, have been recently implicated in cardiovascular diseases including PH. The two critical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypertension, Pulmonary

Share to Hypoxia

Share to Myocytes, Smooth Muscle

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Share to Scavenger Receptors, Class E

Share to Vascular Remodeling

Source

Identifiers

PMID: 36435201
DOI: 10.1016/j.bcp.2022.115350

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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