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Article

P2X7 receptor-mediated phenotype switching of pulmonary artery smooth muscle cells in hypoxia.

Molecular biology reports - 1 Mar 2021

Li Xing, Hu Bing, Wang Li, Xia Qingqing, Ni Xiuqin

Abstract excerpt

P2X7R activation contributes to the pathogenesis of pulmonary hypertension. However, the molecular mechanism through which P2X7R participates in pulmonary vascular remodeling is largely unknown. The rats and pulmonary artery smooth muscle cells (PASMCs) were maintained under hypoxia. P2X7R expression was determined by real-time PCR and western blotting. The pathological changes of lung tissue were evaluated via...

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PMID: 33650080
DOI: 10.1007/s11033-021-06222-2

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