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Article

Local energetic frustration affects the dependence of green fluorescent protein folding on the chaperonin GroEL.

The Journal of biological chemistry - 15 Dec 2017

Bandyopadhyay Boudhayan, Goldenzweig Adi, Unger Tamar, Adato Orit, Fleishman Sarel J, Unger Ron, Horovitz Amnon

Abstract excerpt

The GroE chaperonin system in Escherichia coli comprises GroEL and GroES and facilitates ATP-dependent protein folding in vivo and in vitro Proteins with very similar sequences and structures can differ in their dependence on GroEL for efficient folding. One potential but unverified source for GroEL dependence is frustration, wherein not all interactions in the native state are optimized energetically, thereby...

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Identifiers

PMID: 29066625
DOI: 10.1074/jbc.M117.808576
PMCID: PMC5733594

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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