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Article

GROEL/ES Buffers Entropic Traps in Folding Pathway during Evolution of a Model Substrate.

Journal of molecular biology - 18 Sept 2020

Sadat Anwar, Tiwari Satyam, Verma Kanika, Ray Arjun, Ali Mudassar, Upadhyay Vaibhav, Singh Anupam, Chaphalkar Aseem, Ghosh Asmita, Chakraborty Rahul, Chakraborty Kausik, Mapa Koyeli

Abstract excerpt

The folding landscape of proteins can change during evolution with the accumulation of mutations that may introduce entropic or enthalpic barriers in the protein folding pathway, making it a possible substrate of molecular chaperones in vivo. Can the nature of such physical barriers of folding dictate the feasibility of chaperone-assistance? To address this, we have simulated the evolutionary step to...

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PMID: 32835659
DOI: 10.1016/j.jmb.2020.08.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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