Article
Mapping pathways of allosteric communication in GroEL by analysis of correlated mutations.
Proteins - 1 Sept 2002
Kass Itamar, Horovitz Amnon
Abstract excerpt
An interesting example of an allosteric protein is the chaperonin GroEL. It undergoes adenosine 5'-triphosphate-induced conformational changes that are reflected in binding of adenosine 5'-triphosphate with positive cooperativity within rings and negative cooperativity between rings. Herein, correlated mutations in chaperonins are analyzed to unravel routes of allosteric communication in GroEL and in its complex...
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