Article
ABC transporters and the hallmarks of cancer: roles in cancer aggressiveness beyond multidrug resistance
1 Jan 2020
Abstract excerpt
The ATP-binding cassette transporters (ABC transporters) have been intensely studied over the past 50 years for their involvement in the multidrug resistance (MDR) phenotype, especially in cancer. They are frequently overexpressed in both naive and post-treatment tumors, and hinder effective chemotherapy by reducing drug accumulation in cancer cells. In the last decade however, several studies have established...