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SPERM FACTORS AND EGG ACTIVATION: The structure and function relationship of sperm PLCZ1

6 May 2022

Abstract excerpt

In 2002, sperm-specific phospholipase C zeta1 (PLCZ1) was discovered and through these 20 years, it has been established as the predominant sperm oocyte-activating factor. PLCZ1 cRNA expression or direct protein microinjection into mammalian oocytes triggers calcium (Ca2+) oscillations indistinguishable from those observed at fertilization. The imperative role of PLCZ1 in oocyte activation is revealed by the vast...

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PMID: 35521907
DOI: 10.1530/rep-21-0477

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