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Article

Odocoileus virginianus PRNP sequencing reveals AF (Q95G96/H95G96) advantage over AC (Q95G96/Q95S96) against chronic wasting disease.

Veterinary research - 26 May 2026

London Evan W, Roca Alfred L, Ishida Yasuko, Latif Tooba, Novakofski Jan E, Mateus-Pinilla Nohra E

Abstract excerpt

Chronic wasting disease (CWD) is a highly transmissible spongiform encephalopathy impacting cervids. Variations in the prion protein gene (PRNP), encoding the prion protein (PrP), influence disease progression and susceptibility. Protein sequence is a key determinant of PrP strains and their capacity for interspecies transmission. Sequencing PRNP in white-tailed deer has revealed non-synonymous polymorphisms...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42192487
DOI: 10.1186/s13567-026-01752-8
PMCID: PMC13214280

Genes

PRNP
F2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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