Article

Selective Breeding for Disease Resistant PRNP Variants to Manage Chronic Wasting Disease in Farmed Whitetail Deer

2021-09-06

Abstract excerpt

Chronic wasting disease is a fatal transmissible spongiform encephalopathy (TSE) of cervids caused by a misfolded variant of the normal cellular prion protein, and is closely related to sheep scrapie. Variations in a host’s prion gene, PRNP, and its primary protein structure, dramatically affect susceptibility to specific prion disorders, and breeding for PRNP variants that prevent scrapie infection has led...

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Literature Corpus work: 6e3a23a6-c382-5373-9b7a-aa2cc8108810
DOI: 10.20944/preprints202109.0095.v1

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