Article
Exhaustive search for epistatic effects on the human methylome.
Scientific reports - 20 Oct 2017
Egli Tobias, Vukojevic Vanja, Sengstag Thierry, Jacquot Martin, Cabezón Rubén, Coynel David, Freytag Virginie, Heck Angela, Vogler Christian, de Quervain Dominique J-F, Papassotiropoulos Andreas, Milnik Annette
Abstract excerpt
Studies assessing the existence and magnitude of epistatic effects on complex human traits provide inconclusive results. The study of such effects is complicated by considerable increase in computational burden, model complexity, and model uncertainty, which in concert decrease model stability. An additional source introducing significant uncertainty with regard to the detection of robust epistasis is the...
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