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Article

Linking the genetic architecture of cytosine modifications with human complex traits.

Human molecular genetics - 15 Nov 2014

Zhang Xu, Moen Erika L, Liu Cong, Mu Wenbo, Gamazon Eric R, Delaney Shannon M, Wing Claudia, Godley Lucy A, Dolan M Eileen, Zhang Wei

Abstract excerpt

Interindividual variation in cytosine modifications could contribute to heterogeneity in disease risks and other complex traits. We assessed the genetic architecture of cytosine modifications at 283,540 CpG sites in lymphoblastoid cell lines (LCLs) derived from independent samples of European and African descent. Our study suggests that cytosine modification variation was primarily controlled in local by single...

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Identifiers

PMID: 24943591
DOI: 10.1093/hmg/ddu313
PMCID: PMC4204771

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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