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Article

CDK6 inhibits white to beige fat transition by suppressing RUNX1.

Nature communications - 9 Mar 2018

Hou Xiaoli, Zhang Yongzhao, Li Wei, Hu Alexander J, Luo Chi, Zhou Wenhui, Hu Jamie K, Daniele Stefano G, Wang Jinfeng, Sheng Jinghao, Fan Yongsheng, Greenberg Andrew S, Farmer Stephen R, Hu Miaofen G

Abstract excerpt

Whereas white adipose tissue depots contribute to the development of metabolic diseases, brown and beige adipose tissue has beneficial metabolic effects. Here we show that CDK6 regulates beige adipocyte formation. We demonstrate that mice lacking the CDK6 protein or its kinase domain (K43M) exhibit significant increases beige cell formation, enhanced energy expenditure, better glucose tolerance, and improved...

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Topics

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Share to Adipose Tissue, Brown
Share to Adipose Tissue, White

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Core Binding Factor Alpha 2 Subunit

Share to Cyclin-Dependent Kinase 6

Share to Diet, High-Fat

Share to Metabolic Diseases

Share to Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

Share to Uncoupling Protein 1

Source

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Identifiers

PMID: 29523786
DOI: 10.1038/s41467-018-03451-1
PMCID: PMC5845007

Genes

CDK6
RUNX1

Variants

Provenance

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