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Article

A conserved RNA structural motif for organizing topology within picornaviral internal ribosome entry sites

9 Aug 2019

Abstract excerpt

Picornaviral IRES elements are essential for initiating the cap-independent viral translation. However, three-dimensional structures of these elements remain elusive. Here, we report a 2.84-Å resolution crystal structure of hepatitis A virus IRES domain V (dV) in complex with a synthetic antibody fragment-a crystallization chaperone. The RNA adopts a three-way junction structure, topologically organized by an...

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PMID: 31399592
DOI: 10.1038/s41467-019-11585-z

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