Article
Structural domains within the 3' untranslated region of Turnip crinkle virus.
Journal of virology - 1 Sept 2008
McCormack John C, Yuan Xuefeng, Yingling Yaroslava G, Kasprzak Wojciech, Zamora Rodolfo E, Shapiro Bruce A, Simon Anne E
Abstract excerpt
The genomes of positive-strand RNA viruses undergo conformational shifts that complicate efforts to equate structures with function. We have initiated a detailed analysis of secondary and tertiary elements within the 3' end of Turnip crinkle virus (TCV) that are required for viral accumulation in vivo. MPGAfold, a massively parallel genetic algorithm, suggested the presence of five hairpins (H4a, H4b, and...
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