Article
Profiling of conditionally reprogrammed cell lines for in vitro chemotherapy response prediction of pancreatic cancer.
EBioMedicine - 1 Mar 2021
Lee Hee Seung, Kim Eunyoung, Lee Jinyoung, Park Seung Joon, Hwang Ho Kyoung, Park Chan Hee, Jo Se-Young, Kang Chang Moo, Hong Seung-Mo, Kang Huapyong, Jo Jung Hyun, Cho In Rae, Chung Moon Jae, Park Jeong Youp, Park Seung Woo, Song Si Young, Han Jung Min, Kim Sangwoo, Bang Seungmin
Abstract excerpt
BACKGROUND: The establishment of patient-derived models for pancreatic ductal adenocarcinoma (PDAC) using conventional methods has been fraught with low success rate, mainly because of the small number of tumour cells and dense fibrotic stroma. Here, we sought to establish patient-derived model of PDAC and perform genetic analysis with responses to anticancer drug by using the conditionally reprogrammed cell...
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