Article
Effect of endothelium-specific insulin resistance on endothelial function in vivo.
Diabetes - 1 Dec 2008
Duncan Edward R, Crossey Paul A, Walker Simon, Anilkumar Narayana, Poston Lucilla, Douglas Gillian, Ezzat Vivienne A, Wheatcroft Stephen B, Shah Ajay M, Kearney Mark T, Kearney Mark I
Abstract excerpt
OBJECTIVE: Insulin resistance is an independent risk factor for the development of cardiovascular atherosclerosis. A key step in the development of atherosclerosis is endothelial dysfunction, manifest by a reduction in bioactivity of nitric oxide (NO). Insulin resistance is associated with endothelial dysfunction; however, the mechanistic relationship between these abnormalities and the role of impaired...
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