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Article

TNF-α impairs endothelial function in adipose tissue resistance arteries of mice with diet-induced obesity.

American journal of physiology. Heart and circulatory physiology - 15 Sept 2012

Donato Anthony J, Henson Grant D, Morgan R Garrett, Enz Ryley A, Walker Ashley E, Lesniewski Lisa A

Abstract excerpt

We tested the hypothesis that high fat (HF) feeding results in endothelial dysfunction in resistance arteries of epididymal white adipose tissue (eWAT) and is mediated by adipose tissue inflammation. When compared with normal chow (NC)-fed mice (n = 17), HF-fed male B6D2F1 mice were glucose intolerant and insulin resistant as assessed by glucose tolerance test (area under the curve; HF, 18,174 ± 1,889 vs. NC,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22821989
DOI: 10.1152/ajpheart.00271.2012
PMCID: PMC3468456

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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