Article
Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: a role for reactive oxygen species.
Atherosclerosis - 1 Sept 2013
Gage Matthew C, Yuldasheva Nadira Y, Viswambharan Hema, Sukumar Piruthivi, Cubbon Richard M, Galloway Stacey, Imrie Helen, Skromna Anna, Smith Jessica, Jackson Christopher L, Kearney Mark T, Wheatcroft Stephen B
Abstract excerpt
OBJECTIVE: Systemic insulin resistance is associated with a portfolio of risk factors for atherosclerosis development. We sought to determine whether insulin resistance specifically at the level of the endothelium promotes atherosclerosis and to examine the potential involvement of reactive oxygen species. METHODS: We cross-bred mice expressing a dominant negative mutant human insulin receptor specifically in the...
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