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Article

Novel drug targets in cell wall biosynthesis exploited by gene disruption in Pseudomonas aeruginosa.

PloS one - 1 Jan 2017

Elamin Ayssar A, Steinicke Susanne, Oehlmann Wulf, Braun Yvonne, Wanas Hanaa, Shuralev Eduard A, Huck Carmen, Maringer Marko, Rohde Manfred, Singh Mahavir

Abstract excerpt

For clinicians, Pseudomonas aeruginosa is a nightmare pathogen that is one of the top three causes of opportunistic human infections. Therapy of P. aeruginosa infections is complicated due to its natural high intrinsic resistance to antibiotics. Active efflux and decreased uptake of drugs due to cell wall/membrane permeability appear to be important issues in the acquired antibiotic tolerance mechanisms....

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Identifiers

PMID: 29045498
DOI: 10.1371/journal.pone.0186801
PMCID: PMC5646862

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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