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Article

In vivo functional genomics of Pseudomonas aeruginosa for high-throughput screening of new virulence factors and antibacterial targets.

Environmental microbiology - 1 Dec 2003

Potvin Eric, Lehoux Dario E, Kukavica-Ibrulj Irena, Richard Karine L, Sanschagrin François, Lau Gee W, Levesque Roger C

Abstract excerpt

Pseudomonas aeruginosa is a model for studying opportunistic pathogens that are highly resistant to most classes of antibiotics and cause chronic pulmonary infections. We have developed and adapted a multiplex polymerase chain reaction-based signature-tagged mutagenesis (STM) for high-throughput screening of a collection of 7968 P. aeruginosa mutants in a rat model of chronic respiratory infection. After three...

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PMID: 14641575
DOI: 10.1046/j.1462-2920.2003.00542.x

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